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KMID : 0923620130130050163
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Immune Network
2013 Volume.13 No. 5 p.163 ~ p.167
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Respiratory Syncytial Virus (RSV) Modulation at the Virus-Host Interface Affects Immune Outcome and Disease Pathogenesis
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Tripp Ralph A.
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Abstract
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The dynamics of the virus-host interface in the response to respiratory virus infection is not well-understood; however, it is at this juncture that host immunity to infection evolves. Respiratory viruses have been shown to modulate the host response to gain a replication advantage through a variety of mechanisms. Viruses are parasites and must co-opt host genes for replication, and must interface with host cellular machinery to achieve an optimal balance between viral and cellular gene expression. Host cells have numerous strat-egies to resist infection, replication and virus spread, and on-ly recently are we beginning to understand the network and pathways affected. The following is a short review article covering some of the studies associated with the Tripp labo-ratory that have addressed how respiratory syncytial virus (RSV) operates at the virus-host interface to affects immune outcome and disease pathogenesis.
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KEYWORD
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RSV, Virus-host interface, Disease intervention
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